Spring Selection 2018

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closes 7 Jan 2018

Research Groups

Portrait Brigitte Voit

Brigitte Voit

Synthesis and characterization of functionalized polymers

Previous and Current Research

The group of Prof. Voit is since about 20 years engaged in the field of dendritic polymers with main focus on the imperfectly hyperbranched structures, but also more recently in some perfectly branched dendrimers. Here, the synthesis of these materials covering a variety of condensation and addition type reactions has been strongly explored, followed by an intensive characterization, elucidating the highly branched structures and their different units, looking into structure development and kinetics and making great efforts to develop more reliable molar mass determination methods.

Dendritic polymers are widely used as multifunctional materials with specific properties (dendritic effect of surface groups and globular shape) for potential (bio-)medical and pharmaceutical applications such as e.g. DNA and drug carrier systems. The fundamental interest to understand the role of carbohydrates/oligosaccharides in various biological processes is steadily growing up besides the prerequisite to improve the behavior and the biological properties of dendritic polymers towards biological molecules and systems. In this context, one research interest of us is to focus on the fundamental understanding of the interaction, complexation and encapsulation properties of dendritic polymers with various oligosaccharide architectures to contribute to the development of potential diagnostic and therapeutic agents.

Besides, the field of dendritic polymers, the synthesis of functional polymers and different polymer architectures by free and controlled radical polymerization (RAFT, NMRP, ATRP) as well as cationic polymerization is covered by a variety of activities in the Voit group. Providing biocompatible and bioactive polymer surfaces for studies in biomedical application is one of the major issues of the current research activities. Here, especially the control of cell attachment or cell release on surfaces as well as control of the cell growth and cell differential by the surface chemistry and physical nature is addressed. Similarly, surfaces for biosensors and mimicking biological surfaces with their specific interactions are addressed.

Of special recent interest is the field of different carrier systems based on glycodendrimers, polymersomes or nanocapsules. In Scheme 1, the self-assembly of specific amphiphilic block copolymers to pH sensitive and UV-crosslinkable polymersomes is outlined and the pH sensitive release of doxorubicin.

In addition, polymeric functional and patternable (by UV light or thermal treatment) surfaces were provided for site-specific attachment of nanoobjects, and block copolymers with orthogonally protected segments were synthesized providing highly ordered and stimuli selective nanostructures in thin films. The main objective of these studies is to provide a selective multifunctionality in polymer structures with potential use in microsystems.

Brigitte Voit research: figure
Fig.1: In addition, polymeric functional and patternable (by UV light or thermal treatment) surfaces were provided for site-specific attachment of nanoobjects, and block copolymers with orthogonally protected segments were synthesized providing highly ordered and stimuli selective nanostructures in thin films. The main objective of these studies is to provide a selective multifunctionality in polymer structures with potential use in microsystems.
Future Projects and Goals

Projects within the DIPP will further focus on the integration of specific synthetic binding groups or biomolecules into hydrogels and hydrogel layers on surfaces. Concepts of molecular imprinting and bioconjugation are explored. The concept of various biocompatible and bioactive polymeric globular systems as carrier systems for different biomedical applications (diagnostics, therapy, gene transfection, bioactive coatings) as well as aspects of synthetic biology will be expanded.

In addition, the first successful studies in the field of nanotechnology will be expanded to transfer concepts of selfassembly in polymer science to the use of nano-patterning for e.g. biosensor preparation and in nano-electronics.

Methodological and Technical Expertise
  • In general: expertise in synthetic organic chemistry and polymer chemistry
  • Synthesis of functional polymer architectures and hydrogels
  • Characterization of functional polymer architectures in solution with regard to chemical structure, size, molar mass and interactions e.g. by dynamic  light scattering, size-exclusion chromatography, Flow field flow fractionation (4F), Maldi-TOF, NMR, IR, zeta potential measurements, TEM, AFM, and others
  • Characterization of hydrogels and thin functional polymer films with regard to surface properties and interactions by various methods
Selected Publications

Özyürek Z, Franke K, Nitschke M, Schulze R, Simon F, Eichhorn K-J, Pompe T, Werner C, Voit B.
Sulfated Glyco-copolymers Support Cell Adhesion and Proliferation by Specific Receptor and Growth Factor Binding.
Biomaterials, 30: 1026–1035 (2009)

Fischer M, Appelhans D, Klajnert B, Bryszewska M, Voit B, Rogers M.
The influence of surface functionality of poly(propylene imine) dendrimers on aggregation and propargation of scrapie prion protein.
Biomacromolecules, 11: 1314–132 (2010)

Höbel S, Loos A, Appelhans D, Schwarz S, Seidel J, Voit B, Aigner A
Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): physicochemical and biological properties of DNA and siRNA complexes.
J. Control. Release, 149: 146–158 (2011)

Gaitzsch J, Appelhans, D, Gräfe, D, Schwille P, Voit B.
Photo-crosslinked and pH sensitive polymersomes for triggering the loading and release of cargo.
Chem. Commun., 47: 3466–3468 (2011)

A. Janaszewska, B. Ziemba, K. Ciepluch, D. Appelhans, B. Voit, B. Klajnert, M. Bryszewska
The biodistribution of maltotriose modified poly(propylene) imine (PPI) dendrimers conjugated with fluorescein – proofs of crossing blood brain barrier
New Journal of Chemistry, 36, 350–353 (2012)

Jens Gaitzsch, Dietmar Appelhans, Linge Wang, Giuseppe Battaglia and Brigitte Voit
Synthetic bionanoreactor: Mechanical and chemical control of polymersome membrane permeability
Angewandte Chemie International Edition, 51, 4448–4451 (2012)

Mohamed A. Yassin, Dietmar Appelhans, Rafael G. Mendes,  Mark H. Rümmeli and Brigitte Voit
pH-dependent Release of Doxorubicin from Fast Photo Cross-linkable Polymersomes Based on Benzophenone Units
Chemistry – a European Journal (Chem. Eur. J.), 18 (39), 12227–12231 (2012)

Xin Huang, Nicole Hauptmann, Dietmar Appelhans, Petr Formanek, Simon Frank, Stefan Kaskel, A. Temme, and Brigitte Voit
Synthesis of Hetero-polymer Functionalized Nanocarriers by Combining Surface-Initiated ATRP and RAFT Polymerization
Small, published online August 2012, DOI: 10.1002/smll.201201397 (2012)

Monika Warenda, Anne Richter, Diana Schmidt, Andreas Janke, Martin Müller, Frank Simon, Ralf Zimmermann, Klaus-Jochen Eichhorn, Brigitte Voit, Dietmar Appelhans
Fabricating pH-stable and swellable very thin hyperbranched poly(ethylene imine)-oligosaccharide films as platform for sensing and microfluidic devices: First view on protein adsorption
Macromol. Rapid. Commun., 33, 1466−1473 (2012)

CV

since 2002
Scientific Director of the Leibniz Institute of Polymer Research Dresden (IPF), Germany

since 1997
Head of IPF Institute Macromolecular Chemistry at the Leibniz Institute of Polymer Research Dresden (IPF), Germany

since 1997
C4-professorship (full professor, tenure) for “Organic Chemistry of Polymers” at the Institute of Macromolecular Chemistry and Textile Chemistry of the University of Technology Dresden (TUD), Germany

1992–1997
Research assistant at Technical University Munich (TUM), Chair Macromolecular Materials, Germany

1991–1992
Postdoctoral position at Eastman Kodak in Rochester, NY, USA, Corporate Research Laboratories

1990
PhD graduation (summa cum laude), UBT, Germany

Contact

Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)
Hohe Straße 6
01069 Dresden, Germany

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