Spring Selection 2020

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closes 25 October 2019

Research Groups

Portrait Caghan Kizll

Caghan Kizil

Mechanisms of Induced Plasticity of the Brain

Previous and Current Research

Our goal is to learn from zebrafish how to enable the adult brain to better cope with neurodegenerative disease and regenerate. The main motivation of our research group is to understand the molecular programs for zebrafish brain to induce regenerative stem cell plasticity. The brains of aging humans are prone to neurodegenerative disorders and we are unable to counteract neuronal loss by regenerating lost cells. Patients with neurodegenerative conditions progressively loose neurons yet cannot form new neurons that would replace the lost ones – namely, we humans lack the proper “plasticity response”. We are using zebrafish as a model organism that can regenerate its brain effectively. We try to learn from fish the molecular programs underlying such an aptitude, and developing innovative tools for comparative studies in mammalian brains.

Caghan Kizil Research: Figure
Cartesian dilemma: brain or heart! A thin section of a zebrafish brain that depicts the neurons (red), immune cells (green) and cell nuclei (blue) after inducing Alzheimer’s pathology.
Future Projects and Goals

We use zebrafish, 3D human brain cultures and mouse models of Alzheimer’s disease to investigate:

  • The molecular mechanisms of neural stem cell plasticity and neurogenesis,
  • Comparative aspects of AD pathology in zebrafish, humans and mouse
  • The effects of neuroinflammation (e.g.: Interleukin-4) on neural stem cell proliferation and neurgenesis
Methodological and Technical Expertise

Our main goals are

  • To identify the molecular mechanisms of neural stem cell plasticity and neurogenic ability in adult zebrafish brain
  • To learn from zebrafish how to enable the adult brains to better cope with neurodegenerative disease and regenerate
  • To translate the findings from zebrafish to mammalian models of Alzheimer's disease in 3D hydrogels and mouse
Selected Publications

Kizil C, Bhattarai P
Is Alzheimer’s Also a Stem Cell Disease? – The Zebrafish Perspective.
Front Cell Dev Biol. 6:159 (2018)

Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He S, Antos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C
3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity.
Developmental Cell. 46(1):85–101.e8 (2018)

Cosacak MI, Bhattarai P, Bocova L, Dzewas T, Mashkaryan V, Papadimitriou C, Brandt K, Hollak H, Antos CL, Kizil C
Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.
Scientific Reports. 7(1):12959 (2017)

Bhattarai P, Thomas AK, Cosacak MI, Papadimitriou C, Mashkaryan V, Froc C, Reinhardt S, Kurth T, Dahl A, Zhang Y, Kizil C
IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain.
Cell Reports. 17(4):941–948 (2016)

Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M
Acute inflammation initiates the regenerative response in the adult zebrafish brain.
Science. 338(6112):1353–6 (2012)

CV

since 2014
Helmholtz Young Investigator Group Leader, German Center for Neurodegenerative Diseases (DZNE) Dresden within Helmholtz Association and joint appointment DFG-Center for Regenerative Therapies Dresden (CRTD), TU Dresden

2009–2014
Post-doctoral fellow, DFG-Center for Regenerative Therapies Dresden (CRTD), TU Dresden

2005–2009
Ph.D., Max Planck Institute for Developmental Biology, Tübingen

2003–2005
M.Sc., Max Planck Research School for Molecular Biology, University of Göttingen

1999–2003
B.Sc., Middle East Technical University, Ankara, Turkey

Contact

Center for Regenerative Therapies Dresden (CRTD)
TU Dresden
Fetscherstraße 105
Dresden, Germany

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