Biofunctional polymer materials
Previous and Current Research
Biologically inspired polymer materials can shift the boundaries between living and man-made systems. We work to recapitulate fundamental biological functions such as recognition, assembly, and adaptation in polymer-based, bioconjugated surfaces and engineered matrices.
Charge and structure at bio-interfaces: New tools and methods are developed and implemented to analyze and control ionic charge, molecular transport, supramolecular structure and bioadhesion at solid/liquid interfaces.
Hemocompatible interfaces: Blood-material interactions are systematically explored through whole blood incubation studies that enable the development of anticoagulant coatings containing various types of natural and synthetic inhibitor molecules.
Matrix engineering: Decellularized or reconstituted biopolymer matrices and modular, biofunctional hydrogels are designed to create cell-instructive microenvironments and morphogenetic matrices for regenerative therapies.
Future Projects and Goals
We aim at developing bio-responsive polymer systems to enable in vivo tissue engineering schemes.
Hensel R, Finn A, Helbig R, Braun HG, Neinhuis C, Fischer WJ, Werner C.
Biology-inspired omniphobic surfaces by reverse imprint lithography
Advanced Materials, 26 2029–2033 (2014)
Chwalek K, Tsurkan MV, Freudenberg U, Werner C.
Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models
Scientific Reports 4, 4414 (8pp) (2014)
Maitz MF, Freudenberg U, Tsurkan MV, Fischer M, Beyrich T, Werner C.
Bio-responisve polymer hydrogels homeostatically regulate blood coagulation
Nature Communications, Doi:10.1038/ncomms3168 (2013)
Prewitz M, Seib FP, v Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C.
Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments
Nature Methods, Doi:10.1030/NMETH.2523 (2013)
Sebinger D, Ofenbauer A, Gruber P, Malik S, Werner C.
ECM modulated early kidney development in embryonic organ culture
Biomaterials, 34:6670–82 (2013)