Spring Selection 2018

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currently open
closes 7 Jan 2018

Research Groups

Portrait Carsten Werner

Carsten Werner

Biofunctional polymer materials

Previous and Current Research

Biologically inspired polymer materials can shift the boundaries between living and man-made systems. We work to recapitulate fundamental biological functions such as recognition, assembly, and adaptation in polymer-based, bioconjugated surfaces and engineered matrices.

Charge and structure at bio-interfaces: New tools and methods are developed and implemented to analyze and control ionic charge, molecular transport, supramolecular structure and bioadhesion at solid/liquid interfaces.

Hemocompatible interfaces: Blood-material interactions are systematically explored through whole blood incubation studies that enable the development of anticoagulant coatings containing various types of natural and synthetic inhibitor molecules.

Matrix engineering: Decellularized or reconstituted biopolymer matrices and modular, biofunctional hydrogels are designed to create cell-instructive microenvironments and morphogenetic matrices for regenerative therapies.

Carsten Werner research: figure 1
Fig.1: Heparin-starPEG gel platform decoupled gradation of physical and biomolecular signals
Carsten Werner research: figure 2
Fig.2: (A) Tube like structures formed by endothelial cells grown on biohybrid gels (B) Embryonic kidney of the mouse cultivated in a new developed organ culture system (C) Human hematopoetic stem cell growing within fibronectin-coated microcavities
Future Projects and Goals

We aim at developing bio-responsive polymer systems to enable in vivo tissue engineering schemes.

Selected Publications

Hensel R, Finn A, Helbig R, Braun HG, Neinhuis C, Fischer WJ, Werner C.
Biology-inspired omniphobic surfaces by reverse imprint lithography
Advanced Materials, 26 2029–2033 (2014)

Chwalek K, Tsurkan MV, Freudenberg U, Werner C.
Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models
Scientific Reports 4, 4414 (8pp) (2014)

Maitz MF, Freudenberg U, Tsurkan MV, Fischer M, Beyrich T, Werner C.
Bio-responisve polymer hydrogels homeostatically regulate blood coagulation
Nature Communications, Doi:10.1038/ncomms3168 (2013)

Prewitz M, Seib FP, v Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C.
Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments
Nature Methods, Doi:10.1030/NMETH.2523 (2013)

Sebinger D, Ofenbauer A, Gruber P, Malik S, Werner C.
ECM modulated early kidney development in embryonic organ culture
Biomaterials, 34:6670–82 (2013)

CV

since 2008
Professor for Biofunctional Polymer Materials, Center for Regenerative Therapies Dresden at TU Dresden

since 2000
Adjunct Professor, Institute of Biomaterials and Biomedical Engineering, University of Toronto

since 2000
Head of Department Biomaterials, Leibniz Institute of Polymer Research Dresden/Max Bergmann Center of Biomaterials

1995–2000
Group Leader, Leibniz Institute of Polymer Research Dresden

1998
Dr.rer.nat., TU Dresden

Contact

Leibniz-Institut für Polymerforschung Dresden e.V. (IPF)
Hohe Straße 6
01069 Dresden, Germany

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