Spring Selection 2018

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currently open
closes 7 Jan 2018

Research Groups

Portrait Wieland Huttner

Wieland Huttner

Neurogenesis in the mammalian central nervous system

Previous and Current Research

CNS neurons originate from neuroepithelial cells. We study the cell biological mechanisms underlying the switch of neuroepithelial cells from proliferation to neurogenesis in the mouse embryo. Prior to, during, and as a consequence of, neurogenesis, neuroepithelial cells down-regulate a number of epithelial features. Expression of the antiproliferative gene TIS21 can be used (i) as a tool to distinguish between proliferating and neuron-generating neuroepithelial cells and (ii) as a means of imaging neuron-generating divisions of neuroepithelial cells. To study the distribution, during mitosis, of cellular components in the context of the apico-basal axis of neuroepithelial cells, we have focused on prominin, a pentaspan membrane protein identified by our group that is sorted to the apical surface of neuroepithelial cells and specifically retained in plasma membrane protrusions. Prominin is associated with a novel, cholesterol-based lipid raft.

Future Projects and Goals

Future projects concern the cell biological as well as genomic basis of neurogenesis in the mammalian central nervous system. Our goal is to elucidate, at the molecular level, the switch of neuroepithelial cells from proliferative to neuron-generating division.

Selected Publications

Huttner WB, Kosodo Y.
Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system.
Curr Opin Cell Biol. 2005 Dec;17(6):648-57. (2005)

Gotz M, Huttner WB.
The cell biology of neurogenesis.
Nat Rev Mol Cell Biol. 2005 Oct;6(10):777-88. Review. (2005)

Calegari F, Haubensak W, Haffner C, Huttner WB.
Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development.
J Neurosci. 2005 Jul 13;25(28):6533-8. (2005)

Marzesco AM, Janich P, Wilsch-Brauninger M, Dubreuil V, Langenfeld K, Corbeil D, Huttner WB
Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells.
J Cell Sci. 2005 Jul 1;118(Pt 13):2849-58. (2005)

Kosodo, Y., Röper, K., Haubensak, W., Marzesco, A. M., Corbeil, D. and Huttner, W. B.
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells.
EMBO J., 23, 2314-2324. (2004)

Haubensak, W., Attardo, A., Denk, W. and Huttner, W. B.
Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis.
Proc. Natl. Acad. Sci USA, 101, 3196-32015. (2004)

Calegari, F. and Huttner, W. B.
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis.
J. Cell Sci., 116, 4947-4955. (2003)

CV

since 2002
Honorary Professor of Neurobiology, TU Dresden

since 1998
Director, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden

1991–2000
Professor and Chair, Institute for Neurobiology, University of Heidelberg, Germany

1985–1990
Group Leader, European Molecular Biology Laboratory, Heidelberg, Germany

1981–1985
Junior Group Leader, Max-Planck-Institute for Psychiatry, Department of Neurochemistry, Martinsried, Germany

1979–1980
Research Associate, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA

1977–1979
Post-doctoral Fellow, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA

1976–1977
Post-doctoral Fellow, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany

1976
MD, University of Hamburg, Germany

Contact

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstraße 108
01307 Dresden

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